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Under Diocletian’s new Dominate, the Augusti took the place of the Senate and the assemblies, and thus any decree of an Augustus remained in force even after that particular emperor left office. Such an act could only be invalidated by a future Emperor. The logical extension of this concept meant that neither a magistrate, the assemblies, nor the senate, could legally restrain the Emperor.

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When George Washington died of acute epiglottitis at his Mount Vernon plantation on December 14, 1799, the young nation was stunned. In Philadelphia, which at the time served as the nation’s capital for ten years while the new federal city was being built, Congress selected Henry Lee III to eulogize Washington. Mock funerals were held all over the United States.

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These pathophysiological associations may account in part for the recognized association between MDD and autoimmune diseases, as well as between MDD and osteoporosis. Hormones of the HPT axis, including thyrotropin releasing hormone (TRH), thyroid stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) have been shown to have direct stimulatory effects on immune cells.36,37,38 The effect of thyroid hormones on the immune system can also result from the interaction between the HPT and HPA axes. In rats, hypothyroid states have been shown to reduce the HPA axis responses, while hyperthyroidism increases HPA axis responses.39HPG axisThe HPG axis modulates the immune system both directly through sex hormone effects on immune cells and indirectly through interactions with the HPA axis.