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Amgen (AMGN 1.2%) and development partner AstraZeneca (AZN 0.6%) announce that the Amagine 2 Phase 3 trial evaluating two doses (210 mg and 140 mg every two weeks) of brodalumab in patients with moderate to severe plaque psoriasis met its primary endpoints compared to J (JNJ 0.1%) Stelara (ustekinumab) and placebo at week 12. The 210 mg arm and the weight based analysis group both demonstrated superiority to Stelara on achieving total skin clearance as measured by the Psoriasis Area Severity Index (PASI 100 or 100% reduction in score).44.4% of patients in the brodalumab 210 mg group, 33.6% in the brodalumab weight based group, 25.7% of patients in the brodalumab 140 mg group, 21.7% of patients in the Stelara group and 0.6% of patients in the placebo group achieved PASI 100. The first major secondary endpoint comparing PASI 100 for brodalumab 140 mg against Stelara at week 12 was numerically greater but not statistically significant (p=0.078).
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