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GR does not act as a dominant negative inhibitor in dexamethasone induced transcriptional repression of IL 8The anti inflammatory effects of glucocorticoid are not confined to the synthesis of anti inflammatory proteins, but also rely on the suppression of expression of activated cytokines in the inflammatory conditions. This suppression of activated cytokines is mediated at least in part by transrepression. In contrast to the result of GR effect on the transcriptional activation, GR overexpression did not influence transcriptional repression induced by dexamethasone in the A549 IgG cell line (Figure 4A).

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We were hoping they wouldn show up this year and ruin things for everyone with their blatant disrespect, but I guess we didn scare them enough. I feel your pain, and I sorry you had the displeasure of camping by them. I hope the rest of your forest was good!

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